Oral · Gut · Systemic
Fasolati™
“Oral health is the last unlit corner of systemic health.”
We’re building a clearer picture of how oral health fits into the health of the whole person. Simple enough to use. Deep enough to question.
An evidence-led platform in development
The mouth belongs
in the picture.
Periodontal treatment can improve some systemic markers in defined patient groups. A Cochrane review found improved blood-glucose control in people with both diabetes and periodontitis. Read the clinical review.
That is a reason to investigate the connection, not permission to attribute every inflammatory signal to the mouth. Fasolati’s question is more specific: can we measure something about oral bacterial activity that adds useful information beyond a periodontal exam and bacterial count?
Four questions.
No invisible leaps.
A research map, not a proven chain in an individual. Each step needs its own measurement and evidence.
What is there?
Organisms, bacterial burden, and the local oral environment.
Define the source ↗02 / Effector activityWhat does it release?
Vesicles, associated cargo, and other biologically active material.
Explore the mechanisms ↗03 / Delivered exposureWhat gets through?
Material that reaches another compartment, with its source established.
Examine the human bridge ↗04 / Host responseWhat changes?
A separately measured response, and a test of whether the information helps.
See the next experiments ↗An oral measurement is not a circulating concentration. A biological mechanism is not a personal disease-risk score.
Beyond the
bacterial census.
Outer membrane vesicles, or OMVs, are one type of bacterial extracellular vesicle. Experimental studies show that periodontal-bacterial vesicles can carry active material and trigger different immune responses. Cecil et al., 2016.
Fasolati is interested in function as well as composition: not only which bacteria are present, but what their released material does. The first job is to establish exactly what an assay measures and whether vesicle-associated activity adds information.
Follow the OMV-to-effect map →Connected does
not mean identical.
Human studies have characterized bacterial-vesicle-associated material in blood, including associations with intestinal-barrier dysfunction. They do not establish that a particular person’s circulating material came from the mouth. Tulkens et al.
Our proposed architecture keeps oral observations, gut context, and host-response markers distinct. Agreement can suggest a question worth testing. Disagreement is information too, not something to hide inside a single score.
Simple on the surface.
Inspectable underneath.
The proposed Life Board is organized around three questions, not a mysterious health number. This is a design direction, not a live clinical dashboard.
Explore the Life Board concept →What changed?
The actual measurement, its date, and a comparable prior result. Missing data stays missing.
How sure are we?
Measurement quality and repeatability, kept separate from the strength of the underlying science.
What is the next justified step?
A useful question, a repeat measurement when warranted, or a conversation with a clinician.
Take a closer look.
Explore the concept, question a connection, or help shape what deserves to be built next.
Earn every
connection.
We’re looking for collaborators who can help test the hard parts: assay identity, source attribution, functional activity, and clinical usefulness. A result that changes the hypothesis is progress.
Our oral-care and broader platform programs belong alongside that research, not ahead of it. Product-specific benefit must be established for the finished intervention and the intended use.